Abstract #2805

MRI in Assessing Response to Neoadjuvant Chemo-radiation in Locally Advanced Rectal Cancer Using DCE-MR and DWI Data Sets: Before, During and After the Treatment

Ke Nie¹, Liming Shi², Ning Yue¹, Jabbour Salma¹, Xi Hu², Liwen Qian², Tingyu Mao², Qin Chen², Xiaonan Sun², and Tianye Niu^2,3,4

¹Radiation Oncology, Rutgers-Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, United States, ²Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University of Medicine, Hangzhou, China, People's Republic of, ³Institute of Translational Medicine, Hangzhou, China, People's Republic of, ⁴Radiology, Sir Run Run Shaw Hospital, Zhejiang University of Medicine, Hangzhou, China, People's Republic of

We are one of the first to investigate the predictive value of combined anatomical, DCE-MRI and DWI for good pathological response at different time points during the pre-operative chemo-radiation treatment (CRT) in patients with locally advanced rectal cancer (LARC). The pre-treatment ADC and internal heterogeneity enhancement measured by texture features from DCE-MRI and the relative change of the ADC values during the treatment showed good prognostic value with pathological response. Overall, this study provides new information of the optimal use of MRI in predicting response to the pre-operative CRT, which may further help tailor the treatment into the era of personalized medicine.

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