Abstract #2803

Threshold functional imaging maps depict intra-tumour heterogeneity of response to radiotherapy in retroperitoneal sarcomas

Jessica M Winfield^1,2, Aisha Miah³, Dirk Strauss⁴, Khin Thway⁵, David J Collins^1,2, Martin O Leach^1,2, Sharon L Giles^1,2, Daniel Henderson³, Shane Zaidi⁶, and Christina Messiou^1,2

¹MRI, Royal Marsden Hospital, Sutton, United Kingdom, ²Division of Radiotherapy and Imaging, Cancer Research UK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom, ³Department of Radiotherapy, Royal Marsden Hospital, London, United Kingdom, ⁴Department of Surgery, Royal Marsden Hospital, London, United Kingdom, ⁵Department of Histopathology, Royal Marsden Hospital, London, United Kingdom, ⁶Department of Clinical Oncology, Royal Marsden Hospital, London, United Kingdom

Functional imaging provides scope for non-invasive assessment of response to radiotherapy and/or systemic agents in retroperitoneal sarcomas and investigation of heterogeneity of response in this highly heterogeneous tumour type. In this study 9 patients with retroperitoneal sarcoma were imaged before treatment and 2-4 weeks after radiotherapy. Whilst some tumours exhibited large increases in median ADC and enhancing fraction after radiotherapy, the overall changes for the cohort were not significant and there were no clear changes in fat fraction. Thresholded ADC maps and enhancement maps, however, reveal localised post-radiotherapy changes in ADC and enhancement that are not fully characterised by whole-tumour metrics.

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