Abstract #2800

Lung tumour radiotherapy treatment response assessment using Active Breathing Coordinated (ABC) Diffusion-Weighted Magnetic Resonance Imaging

Evangelia Kaza¹, Matthew Blackledge¹, David John Collins¹, Erica Scurr², Helen McNair³, Richard Symonds-Tayler¹, Fiona McDonald², Martin Osmund Leach¹, and Dow-Mu Koh²

¹The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, ²The Royal Marsden NHS Foundation Trust, London, United Kingdom, ³Department of Radiotherapy, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom

Imaging with an Active Breathing Coordinator (ABC) modified for MR use was performed on lung cancer patients to acquire spatially matching diffusion-weighted images (DWI) before, during and after Radiotherapy. DWI spatially matched the CT and depicted mediastinal nodal involvement as well as internal tumour heterogeneity. ADC maps provided information about changes in solid and fluid components throughout therapy. Treatment response was evaluated by applying multi-parametric tumour heterogeneity characterisation using Gaussian Mixture Modelling. Differences in ADC and volume behavior of separate cancerous tissue components at various treatment time points may indicate tumour sub-volumes and provide detailed cancer characterisation.

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