Abstract #2770

Measurement of Arteriolar Blood Volume in Brain Tumors Using MRI without Exogenous Contrast Agent Administration at 7T

Yuankui Wu^1,2,3, Shruti Agarwal⁴, Craig K Jones^2,3, Andrew G Webb⁵, Peter C.M. van Zijl^2,3, Jun Hua^2,3, and Jay J Pillai⁴

¹Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, ²Neurosection, Div. of MRI Research, Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Radiology, C.J.Gorter Center for High Field MRI, University Medical Center, Leiden, Netherlands

The purpose of this study is to evaluate the potential diagnostic value of inflow-based vascular-space-occupancy (iVASO) MRI in brain tumor patients by comparing it with the widely used dynamic-susceptibility-contrast (DSC) MRI. The iVASO approach can measure arteriolar cerebral blood volume (CBVa) without using an exogenous contrast agent. The measured CBVa by iVASO showed a stronger association with tumor grade than DSC CBV. As the total scan times for iVASO and DSC are comparable, iVASO MRI may be a useful alternative for the assessment of tumor perfusion, especially when exogenous contrast agent administration is difficult or contraindicated in certain patient populations.

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