Natalie M Schenker-Ahmed1, Ghiam Yamin1, Ahmed Shabaik1, Dennis Adams1, Hauke Bartsch1, Joshua Kuperman1, Nathan S White1, Rebecca A Rakow-Penner1, Kevin McCammack1, J Kellogg Parsons1, Christopher Kane1, Anders Dale1, and David Karow1
Current
multiparametric magnetic resonance imaging techniques for detecting prostate
cancer are limited with respect to tumor conspicuity assessment, in vivo characterization and
localization. We
demonstrate that a novel diffusion-based MRI technique, restriction spectrum
imaging (RSI-MRI), differentiates among benign, low-grade and high-grade PCa at
voxel-level resolution. Using an RSI-MRI index to differentiate between low-
and high-grade categories of tumor PCa aggressiveness may help improve and
refine diagnosis and staging of PCa.
Additionally, because it can detect intratumor variation, RSI-MRI may
have particular relevance for planning targeted therapies such as radiation
seed therapy placement, MR-guided focused ultrasound surgery, and MR-guided
targeted biopsy.
