Abstract #2748

Prostate tissue microstructure: Complementary assessment using multifrequency MR elastography and diffusion tensor imaging in ex vivo human prostate tissue.

Lynne E. Bilston^1,2, Lauriane Jugé ^1,3, and Roger Bourne⁴

¹Neuroscience Research Australia, Randwick, NSW, Australia, ²Prince of Wales Clinical School, University of New South Wales, Kensington, NSW, Australia, ³School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia, ⁴Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Lidcombe, NSW, Australia

MR elastography (MRE) and diffusion weighted imaging (DWI) techniques are sensitive to microstructural changes, as reflected in the tissue stiffness and water diffusion properties respectively. These results showed that mechanical and diffusion properties varied between fresh and fixed prostate tissue, but were not highly correlated with each other, suggesting that multifrequency MRE and DWI have the potential to be complementary imaging tools for tracking the alterations in soft tissue microstructure, such as those that occur in cancer and other diseases.

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