Abstract #2651

Evaluation of the tCho and β-catenin concentration with different molecular biomarkers in breast cancer patients

Khushbu Agarwal¹, Gururao Hariprasad², Komal Rani², Uma Sharma¹, Sandeep Mathur³, Vurthaluru Seenu⁴, Rajinder Parshad⁴, and Naranamangalam R Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, Delhi, India, ²Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India, ³Department of Pathology, All India Institute of Medical Sciences, Delhi, India, ⁴Department of Surgical Disciplines, All India Institute of Medical Sciences, Delhi, India

We evaluated the correlation of tCho and β-catenin concentrations were correlated with molecular biomarkers (ER, PR and Her2neu) in breast cancer patients. The nuclear β-catenin expression was significantly higher compared to cytosolic expression. A positive correlation between tCho and β-catenin (cytosolic and nuclear fractions) concentrations was seen. The PR- tumors had significantly higher cytosolic β-catenin compared to PR+ tumors. This may be because progesterone acts as an inhibitor of Wnt pathway and thus its absence may lead to increased cytosolic β-catenin in PR- tumors. Results demonstrated role of tCho, β-catenin and progesterone in breast cancer progression.

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