Hemant Parmar1, Daniel Wahl2, Priyanka Pramanik2, Michelle Kim2, Theodore S Lawrence2, and Yue Cao1,2
1Radiology, University of Michigan, Ann Arbor, MI, United States, 2Radiation Oncology, University of Michigan, Ann Arbor, MI, United States
Standard imaging for glioblastoma relies on post-contrast T1
and T2 FLAIR MRI sequences, which do not accurately reflect tumor biology. Advanced
MRI techniques can define biologically relevant and prognostic features of glioblastoma
including perfusion-based volumes with high cerebral blood volume (VhCBV)
and high b-value diffusion-based hypercellular subvolume (HCV). We defined VhCBV
and HCV in 24 patients with glioblastoma prior to undergoing
chemoradiation. Surprisingly, there was little overlap between VhCBV
and HCV within individual patients, which suggests that these volumes represent
distinct aspects of tumor biology and may be independently prognostic. Analysis
of failure patterns and prognostic relevance is ongoing.
