Abstract #2635

Longitudinal Diffusion MRI for Treatment Response Assessment: Preliminary Experience using an MRI-Guided tri-Cobalt 60 Radiotherapy System

Yingli Yang¹, Minsong Cao¹, Ke Sheng¹, Yu Gao², Allen M Chen¹, Mitchell Kamrava¹, Percy Lee¹, Nzhde Agazaryan¹, James Lamb¹, David H Thomas¹, Daniel A Low¹, and Peng Hu²

¹Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States, ²Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States

Diffusion weighted MRI is promising for early prediction of response to radiotherapy 1, 2, and for adaptive radiotherapy, wherein the treatment plan is adapted during treatment based on patients’ response assessed by imaging. Currently DWI-based adaptive radiotherapy is not widely adopted because of scientific and practical challenges. Most importantly, the timing for DWI imaging is not well studied without longitudinal diffusion MRI data at a finer time interval (every 2-5 days) throughout the course of treatment. A recently commercialized MRI-guided radiotherapy system (ViewRay) may eliminate the current challenges and bring diffusion MRI-guided adaptive radiation therapy closer to clinical utility.

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