Abstract #2588

Velocity Transfer Function from Phase Contrast MRI - A Non-Invasive Method for Assessing Pulmonary Arterial Stiffness and Impedance

Himanshu Gupta^1,2, Ankur Gupta¹, and Thomas S Denney^3,4

¹Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States, ²VA Medical Center, Birmingham, AL, United States, ³Auburn University MRI Research Center, Auburn University, Auburn, AL, United States, ⁴Electrical and Computer Engineering, Auburn University, Auburn, AL, United States

Pulmonary arterial (PA) impedance accounts for pulsatile blood flow through elastic pulmonary arteries as compared to static pulmonary vascular resistance. Increased PA impedance is an early physiological manifestation of PA remodeling. Currently, PA impedance can only be detected invasively, is expensive and cumbersome to calculate and not done in routine clinical practice. Non-invasive assessment of PA impedance can provide insights in evaluation of patients with normal PA pressures or mild pulmonary hypertension such as in patients with chronic obstructive lung disease. We propose a novel non-invasive parameter, the velocity transfer function (VTF), which is related to PA stiffness and impedance.

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