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Abstract #2510

Assessment of cHSA-PEO (2000)16-Gd in breast cancer xenografts on chicken chorioallantoic membrane @ 11.7T

Zhi Zuo1,2,3, Tatiana Syrovets4, Tao Wang5, Yu-zhou Wu5, Felicitas Genze4, Alireza Abaei3, Ina Vernikouskaya2, Wei-na Liu5, Gen-shan Ma1, Tanja Weil5, Thomas Simmet4, and Volker Rasche2,3

1Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China, People's Republic of, 2Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany, 3Core Facility Small Animal MRI, Medical Faculty, Ulm University, Ulm, Germany, 4Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany, 5Institute of Organic Chemistry III, Ulm University, Ulm, Germany

High-resolution MRI and chicken chorioallantoic membrane (CAM) cancer xenografts model are employed for the assessment of bio-distribution of polypeptide hybrid biomaterials cHSA-PEO (2000)16-Gd. The breast carcinomas were planted on the CAM, which were intravascular injected with cHSA-PEO (2000)16-Gd, gadofosveset (Vasovist®) and gadobenate dimeglumine (Multihance®) before MR scanning. The detailed internal structures of tiny cancer were clearly highlighted, which was proven by the immune-histological analysis. Assessment of the bio-distribution of contrast agents renders feasible. The cHSA-PEO (2000)16-Gd has exhibited an improved specific tissue uptake by cancer cell xenografts and long lasting enhancement compared to traditional contrast agents.

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