Esophageal carcinoma: ex vivo high resolution MR imaging study compare with histopathological findings
Yi Wei1,2, Shao-Cheng Zhu1,2, Sen Wu1,2, Da-Peng Shi1,2, and Dan-Dan Zheng3
1Radiology, Zhengzhou University People's Hospital, Zhengzhou, China, People's Republic of, 2Henan Provincial People's Hospital, Zhengzhou, China, People's Republic of, 3GE Healthcare,MR Research China, Beijing, China, People's Republic of
The prognosis of patients with esophageal carcinoma is heavily dependent on the histopathological staging of the carcinoma. However, the common examination modalities are extremely difficult to identify the preoperative staging. Magnetic resonance imaging (MRI) was reported to evaluate the esophageal layers invasion in vitro and demonstrated that high-resolution T2-weighted imaging can clearly depict 8 layers of the esophagus which can provide essential information of the carcinoma invasion. However, former studies were mostly carried on ultra-high-field scanner after formalin fixed within 24 hours ex vivo, which might cause the signal changes of the esophageal layers and carcinoma. In this study, an ex vivo experiment was conducted on 3.0T clinical scanner to prospectively establish the MRI signal characteristics of the normal esophageal wall without formalin fixation and to assess the diagnostic accuracy of high-resolution MR scanner for depicting the depth of esophageal wall invasion by making the correspondence with certain histopathological slice.
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