Xiaobing Fan1, Shiyang Wang1, Milica Medved 1, Tatjana Antic2, Serkan Guneyli 1, Gregory S Karczmar1, and Aytekin Oto1
1Radiology, University of Chicago, Chicago, IL, United States, 2Pathology, University of Chicago, Chicago, IL, United States
Previous
dynamic contrast enhanced (DCE) MRI studies demonstrated that stromal benign
prostatic hyperplasia (BPH) nodules are difficult to differentiate from
transition zone prostate cancer (PCa). Therefore, it is important to improve
the accuracy of DCE-MRI to distinguish BPH from PCa. A total of 24 patients
with biopsy confirmed PCa were enrolled in this study. DCE-MRI data were
acquired at 3 T for a total of ~8.3 minutes. The relative signal enhancement curves
for cancer (n=24) and BPH (n=19) were calculated and analyzed using an empirical
mathematical model. The ratio of washout-rate/uptake-rate (p<0.01) was
significantly smaller in BPH than in cancers.
