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Abstract #2485

3D MRI Breast Density Change in Women with Hormonal Positive Breast Cancer Following Adjuvant Hormonal Therapy

Yoon Jung Choi1, Jeon-Hor Chen2,3, Shunshan Li2, Po-Han Chen4, Pei-Yu Liu4, Inyoung Youn1, and Min-Ying Su2

1Department of Radiology, Kangbuk Samsung Hospital, Seoul, Korea, Republic of, 2Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States, 3Department of Radiology, Eda Hospital and I-Shou University, Kaohsiung, Taiwan, 4Department of Medical Imaging, China Medical University, Taichung, Taiwan

Hormonal regimens may affect breast tissue with the change of breast volume or composition. This study was to apply a well-established breast and fibroglandular tissue segmentation method to analyze the density changes in patients receiving adjuvant hormonal therapy. The results showed that pre-menopausal women had a higher density reduction, presumably due to their more abundant fibroglandular tissues that can be decreased, but a high variation was observed. The density reduction assessed by 3D MRI may be used as a surrogate marker to correlate with metabolic genotyping, and further used in combination to better predict patient’s prognosis.

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