Pharmacokinetic (PK) models have been used to
estimate physiological parameters such as permeability and dispersion of the
contrast agent and is estimated using the acquired signal, pre-contrast T10,
and the acquisition flip angle. In this work, we have determined the dependence
of the dispersion models’ and
Tofts models’ PK
parameters on T10 and B1 maps, as well as the errors introduced by using
constant T10 and B1 values in 11 biopsy-proven tumors. Our
results show that PK parameters such as kep of Tofts model and kappa
of mLDRW dispersion model are less dependent on T10 and B1
and could potentially be used with higher accuracy and precision even when T10
and B1 maps are not acquired.
