Virendra Kumar1, Tanmoy Bagui2, Rashmi Mukherjee2, Vertika Rai2, Pawan Kumar1, and Chandan Chakraborty2
1Department of NMR, All India Institute of Medical Sciences, New Delhi, India, 2School of Medical Science & Technology, Indian Institute of Technology Kharagpur, Kharagpur, India
Diabetic
retinopathy (DR), is a major cause of blindness, caused by prolonged diabetes.
However, this morbidity is largely preventable and treatable. The progression
of DR from prolonged diabetes involves complex metabolic de-regulations. 1H
NMR-based metabolomics of serum have potential to study dysregulation in
metabolites of DR patients. Results of the PCA and PLS-DA analysis revealed
metabolic differences in DR patients compared to healthy subjects. Using such a
study, we may observe the severity of disease based on metabolic fingerprints and
it may serve as a platform for screening of molecular targets for a more
efficient therapeutic intervention.
