Abstract #2416

High Resolution 1H NMR-based Metabolomics study of Serum in Parkinson’s disease

Pawan Kumar¹, Sadhana Kumari¹, Senthil S Kumaran¹, Shefali Chaudhary¹, Vinay Goyal², Madhuri Behari², S N Dwivedi³, Achal Srivastava², and Naranamangalam R Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

We used ¹H NMR technique to investigate the serum samples of 6 patients with Parkinson’s disease (PD) and 6 healthy controls (HC) using 700 MHz NMR spectrometer and the data were processed using the Agilent software, Vnmrj2.3A. PLS-DA multivariate analysis was performed to explore biochemical dissimilarities between PD patients and HC using MetaboAnalyst (3.0) software. We observed significantly elevated levels of lactate, glutamate and methyl guanidine PD patients in comparison with HC on t-test, suggesting protein metabolism impairment, mitochondrial dysfunction and oxidative stress in PD patients.

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