Abstract #2398

Cerebral Acetate Transport and Utilization in the Rat Brain in vivo using 1H MRS: Consequences of a revised acetate volume of distribution value

Masoumeh Dehghani M.¹, Bernard Lanz¹, Nicolas Kunz², Pascal mieville³, and Rolf Gruetter^1,2,4,5

¹Laboratoire d'imagerie fonctionnelle et métabolique(LIFMET), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Centre d’Imagerie Biomedicale(CIBM), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Department of Radiology, University of Lausanne, Lausanne, Switzerland, ⁵Department of Radiology, University of Geneva, Geneva, Switzerland

Metabolic modeling of metabolite ¹³C turnover curves in brain with ¹³C-labeled acetate infused as tracer substrate requires prior knowledge of the transport and uptake kinetics of Ace. The aim of this study was to determine the kinetics of transport and utilization for acetate uptake in the rat brain using specific distribution volume of Ace(V_d) in the rat brain. The dependency of estimated CMR_ace to distribution volume of Ace in the rat brain highlights the importance about a refined determination of V_d for Ace in brain metabolic studies.

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