Marissa E. Fisher1, Brennen J. Dobberthien1, Anthony G. Tessier1,2, and Atiyah Yahya1,2
1Department of Oncology, University of Alberta, Edmonton, AB, Canada, 2Department of Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada
The Cho peak at 3.2 ppm contains significant signal contamination from
the taurine (Tau) resonance in rat and mouse brain spectra, even at the high
field strength of 9.4 T. The purpose of this work it to
optimise TE1 and TE2 (echo times) of a Point RESolved
Spectroscopy (PRESS) sequence to minimize Tau signal in the Cho spectral region at 9.4 T by exploiting the J-coupling evolution of the Tau protons. The determined optimal {TE1,
TE2} combination was found to be {25 ms, 50
ms}. The efficacy of the timings was
verified on rat brain in vivo.
