Assessment of serine quantification reproducibility using advanced 1H-MRS in the human brain at 3T
Homa Javadzadeh1,2 and Jean Théberge1,2,3
1Department of Medical Biophysics, University of Western Ontario, London, ON, Canada, 2Imaging Division, Lawson Health Research Institute, London, ON, Canada, 3Diagnostic Imaging Department, St. Joseph's Health Care, London, ON, Canada
D-serine supplements
alleviate some of the most debilitating features of schizophrenia believed to
be associated with glutamatergic abnormalities. Assessment of
endogenous serine is impossible using standard proton Magnetic Resonance
Spectroscopy (1H-MRS). This work employs a novel 1H-MRS
sequence called DANTE-PRESS (D-PRESS) and presents test-retest
reliability study for serine levels acquired at 3T in phantoms and
initial data in two human subjects. We conclude that
reproducibility and precision of serine measurements on a 3.0T scanner
is sufficient to assess endogenous levels in vivo and is a
valuable tool to examine abnormalities in schizophrenia and monitor
supplementation.
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