Abstract #2369

Simultaneous modeling of spectra and apparent diffusion coefficients.

Victor Adalid Lopez¹, André Doering¹, Sreenath Pruthviraj Kyathanahally ¹, Christine S. Bolliger¹, and Roland Kreis¹

¹Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland

Diffusion weighted spectroscopy can provide information on the diffusion of metabolites and the microstructure of brain tissue. A method for simultaneous fitting of spectra related by mono-exponential diffusion weighting is introduced, which is similar to simultaneous fitting of a 2DJ or inversion recovery data set. As shown for simulated white matter data, the method improves both, accuracy and precision of ADC estimation for all metabolites. It is also illustrated with diffusion data obtained from human gray matter at 3T.

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