Abstract #2365

Accounting for GABA editing efficiency and macromolecule co-editing to allow inter-vendor comparisons of GABA+ measurements

Ashley D Harris^1,2,3,4,5, Nicolaas AJ Puts^1,5, Laura Rowland⁶, S. Andrea Wijtenburg⁶, Mark Mikkelsen⁷, Peter B Barker^1,5, C. John Evans⁷, and Richard AE Edden^1,5

¹FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²CAIR Program, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ³Radiology, University of Calgary, Calgary, AB, Canada, ⁴Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Calgary, AB, Canada, ⁵Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ⁶Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States, ⁷CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom

Differences in GABA+ MEGA PRESS acquisitions between vendors are quantified in terms of the editing efficiency of GABA and the fractional co-editing of macromolecules. Accounting for these two parameters results in moderate agreement among the different vendors considered.

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