Abstract #2357

Measurement reproducibility of the spiral encoding GABA-edited MEGA-LASER 3D-MRSI in the brain at 3T

Petra Hnilicová¹, Michal Považan², Bernhard Strasser², Ovidiu C Andronesi³, Dušan Dobrota¹, Siegfried Trattnig², and Wolfgang Bogner²

¹Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ²Department of Biomedical Imaging and Image-guided Therapy, MR Center of Excellence, Medical University of Vienna, Vienna, Austria, ³Department of Radiology, Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, United States

In vivo assessment of neurotransmitter levels can improve the understanding of several pathological processes. For non-invasive GABA⁺ and Glx mapping in vivo within one scan, we applied a spiral-encoded GABA-edited MEGA-LASER 3D-MRSI sequence with real time corrections, achieving the ~3 cc nominal resolution in ~20 minutes. Via test-retest assessment in 14 healthy volunteers (7 men/7 women) we confirmed the measurement reproducibility and inter- and intra-subject variability of GABA⁺ and Glx ratios and thus validated that our method may be used in (pre)clinical studies of neurotransmitters alterations in the brain at 3T.

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