Gilbert Hangel1, Bernhard Strasser1, Michal Považan1, Martin Gajdošík1, Stephan Gruber1, Marek Chmelík1, Siegfried Trattnig1,2, and Wolfgang Bogner1
1MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria
Reliable lipid suppression is essential for robust
quantification of parallel imaging accelerated high-
resolution MRSI. This work compared the performance of non-selective
lipid suppression using double inversion recovery (DIR) with the application of
L1- and L2-regularisation during data processing for single-slice MRSI with a
64×64 matrix and a GRAPPA-acceleration of nine in five volunteers. While DIR
featured the best lipid suppression, it increased the measurement time and
reduced metabolite SNR. L1 and L2 did not have these downsides, but twice as
much lipid signal remained, with L1 increasing the data pre-processing time
before spectral quantification by a factor of six.
