Abstract #2350

Toward Spectroscopically Selective Imaging of Hyperpolarized Pyruvate and its Metabolites Using Binomial Pulses In Balanced Steady-State Free Precession

Gopal Varma¹, Patricia Coutinho de Souza¹, Leo Tsai¹, Rupal Bhatt², and Aaron Grant¹

¹Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, ²Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Balanced steady-state free-precession (bSSFP) offers high sensitivity and good temporal resolution, and makes efficient use of hyperpolarized magnetization. Several strategies for spectroscopically selective imaging with bSSFP have been proposed [1-5]. Here we investigate the use of simple binomial excitation pulses to selectively null the signals from either pyruvate or lactate, the two dominant metabolites in tumors, thereby obtaining images that are dominated by either lactate or pyruvate, respectively. The method is robust to off-resonance effects, and can be used to augment existing spectroscopic bSSFP techniques.

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