Abstract #2343

Optimization and application of bipolar gradient for flow-suppressed hyperpolarized 13C CSI in mouse liver at 9.4T

Hansol Lee¹, Joonsung Lee², Eunhae Joe¹, Seungwook Yang¹, Jae Eun Song¹, Young-suk Choi³, Eunkyung Wang³, Ho-Taek Song³, and Dong-Hyun Kim¹

¹Department of Electrical & Electronic Engineering, Yonsei university, Seoul, Korea, Republic of, ²Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, Korea, Republic of, ³Department of Radiology, Yonsei University College of Medicine, Seoul, Korea, Republic of

In hyperpolarized ¹³C MRI, high signal intensity of vasculature can cause errors in quantification of metabolites or conversion rate constants. The bipolar gradient was used to suppress vascular signal for accurate quantification. However, the velocity of vessel can vary depending on anesthetic level and pulsation. Furthermore, additional T₂* relaxation signal loss can be induced by delayed data acquisition in ultra-high field (9.4T) due to short T₂*. In this study, the bipolar gradient was optimized to minimize additional signal loss and mitigate variable velocity, then the optimized bipolar gradient was implemented for hyperpolarized ¹³C CSI and applied to mouse liver experiment.

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