Sergey Korchak1, Wolfgang Kilian1, Leif Schröder2, and Lorenz Mitschang1
The reversible binding of xenon to host
structures is fundamental to the development of novel contrast agents employing
hyperpolarized xenon and chemical exchange saturation transfer (HyperCEST) for
molecular imaging. The rates for entering and leaving the host depend on atomic
details and affect the obtainable contrast rendering them pivotal for the
selection of hosts and optimization of imaging methods. However, different
exchange processes may apply whose contributions are difficult to assign. Exchange
spectroscopy experiments are proposed which enable straightforward
disentanglement of the exchange kinetics and quantification of individual
contributions. The approaches are exemplified for the cryptophane-xenon
host-guest system.
