Harikrishna Rallapalli1, Eugenia Rafaela Volkova1, I-Li Tan2, Alexandre Wojcinski2, Alexandra L Joyner2, and Daniel H Turnbull1
1Skirball Institute and Radiology, New York University School of Medicine, New York, NY, United States, 2Developmental Biology, Sloan Kettering Institute, New York, NY, United States
In this work, we describe
a powerful longitudinal Manganese-enhanced magnetic resonance imaging (MEMRI)
strategy to characterize a novel mouse medulloblastoma model. An activated Smoothened mutation was engineered to
induce proliferative growth in the cerebellum. Lesions were monitored using
MEMRI up to postnatal day P100, and 3D tumors were segmented for quantitative
volumetric analysis. Qualitative analysis has shown a ~50% chance of regression
overall (n=21), and preliminary quantitation has suggested a combined
progression/regression growth model. With this model, we aim to guide
diagnostic decisions from early timepoints and quantify therapeutic efficacy.
