Interaction of Manganese and Iron in R1 mapping in a Low Concentration Setting
Chien-Lin Yeh1, Carlos J. Perez-Torres1, and Ulrike Dydak1,2
1School of Health Sciences, Purdue University, West lafayette, IN, United States, 2Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States
Being
able to use MRI to estimate brain Mn accumulation is of high interest in
occupational Mn exposure settings. As a first step towards absolute
quantification of brain Mn concentration in exposed humans using MRI, the
interaction between Mn and Fe and their combined effect to R1 need to be
explored. Our results suggest that a model only assuming independent linear contributions
of Mn and Fe already explains the R1 data well. However introducing a cross
term of Mn and Fe in the equation improves the fits, suggesting a Mn-Fe
interaction.
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