Abstract #2313

Combining Multi-therapy in Singlet Vehicle

Yuqi Yang¹, Shizhen Chen¹, Sha Li¹, Lianhua Liu¹, and Xin Zhou¹

¹Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of

Two types of water-insoluble texphyrins (TP), anticancer drug Gd-TP and photosensitizer Lu-TP, were synthesized and loaded onto RGD-functionalized graphene quantum dots (GQDs) via π-π stacking. The obtained complex could be used as a MRI-fluorecent imaging multi-model probe for cancer therapy. Compared with conventional photodynamic therapy (PDT), our method demonstrated better therapy efficiency for deeper tissue, because a laser with longer wavelength was applied to active the photosensitizer Lu-TP. Furthermore, reactive oxygen species resulted from the reaction between redox active drug Gd-TP and cellular reducing metabolites and photothermal effect from GQDs led cancer cells more impressionable to PDT from Lu-TP.

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