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Abstract #2311

Vascular-targeted Magnetic Nanoparticles for Image-guided Cancer Therapy

Sudath Hapuarachchige1, Robert Ivkov2, and Dmitri Artemov1

1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Bionized nanoferrites are magnetic nanoparticles, which can be used as contrast agents and therapeutic platforms for alternating magnetic field (AMF) induced hyperthermia. One important application is enhancing of vascular permeability in tumors for delivery of nanodrugs. We studied BNF nanoparticles specifically targeted to the tumor vasculature via VEGF receptors ligands. Targeted BNF particles were visualized by intravital multiphoton and MR imaging, and increased accumulation of targeted BNF was detected in breast cancer models.

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Abstract