Noam Ben-Eliezer1,2, Akio Ernesto Yoshimoto2, KAI Tobias Block1,2, Roy Davidovitch3, Thomas Youm3, Robert Meislin3, Michael Recht1,2, Daniel K Sodickson1,2, and Riccardo Lattanzi1,2
1Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, 2Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Department of Orthopedic Surgery, New York University Hospital for Joint Diseases, New York, NY, United States
Early diagnosis
of cartilage defects is critical for the success of corrective surgical
procedures in patients with femoroacetabular impingement (FAI). T2 is a biomarker for
early biochemical degeneration of cartilage, but in vivo T2 mapping
is challenging while commonly used techniques based on exponential fit of multi
spin-echo protocols are inaccurate. We used a Bloch simulation based T2 mapping
technique – the EMC algorithm – to retrospectively quantify reliable T2
values in the hip cartilage of FAI patients. We then defined a normalized T2-index
using an internal reference and showed that it allows detection of surgically confirmed
cartilage lesions with 95% accuracy.