Quantitative magnetization transfer MRI of in-situ and ex-situ meniscus
Mikaël Simard1, Emily J. McWalter2, Garry E. Gold2, and Ives R. Levesque1,3
1Medical Physics, McGill University, Montreal, QC, Canada, 2Radiology, Stanford University, Stanford, CA, United States, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Quantitative magnetization transfer (QMT) probes
macromolecular content in tissue and may be a useful tool in the early detection
of meniscal degeneration. QMT mapping of the meniscus was performed in 3
cadaver knee specimens in situ, and
repeated ex situ following dissection
and immersion in perflubron. After extraction, a decrease in the restricted
pool fraction f was noted, while T1obs and T1f increased. A trend towards lower values of the exchange rate kf was noted after excision. T2 and T2r were relatively constant. The variation in QMT parameters may
be caused by the diffusion of perflubron into the ex situ samples.
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