Abstract #2253

Toward a 7T MRI protocol for the evaluation of early osteoarthritis in knee cartilage

Daniel J. Park¹, Neal K. Bangerter^2,3, Antony J. R. Palmer¹, Haonan Wang², Bragi Sveinsson⁴, Brian Hargreaves⁴, and Siôn Glyn-Jones¹

¹Nuffield Department of Orthopaedics, Rheumotology, and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States, ³Department of Radiology, Univerisity of Utah, Salt Lake City, UT, United States, ⁴Radiology, Stanford University, Stanford, CA, United States

Osteoarthritis, a disease that is a burden to society and individuals, has 3 major stages of progression in cartilage: (1) glycosaminoglycan loss; (2) collagen matrix degeneration; and (3) fissures and volume and thickness loss. A protocol is proposed to measure the progression of each of these stages of OA at 7 Tesla in about 30 minutes: (1) T1ρ to measure glycosaminoglycan changes; (2) modified DESS measurements of T2 and ADC to measure collagen matrix integrity; and (3) high resolution phase cycled bSSFP images to measure changes in morphology.

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