Abstract #2249

Quantitative knee cartilage T2 mapping with in situ mechanical loading using prospective motion correction

Thomas Lange¹, Benjamin R. Knowles¹, Michael Herbst^1,2, Kaywan Izadpanah³, and Maxim Zaitsev¹

¹Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ²John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States, ³Department of Orthopedic and Trauma Surgery, University Medical Center Freiburg, Freiburg, Germany

Robust T2 mapping of knee cartilage with in situ mechanical loading using prospective motion correction is demonstrated for the patellofemoral and tibiofemoral knee compartments. T2 maps are reconstructed from multiple spin-echo data acquired with slice position updates before every excitation. While T2 maps of the tibiofemoral joint do not show significant changes in response to loading, maps of the patellofemoral joint show a substantial load-induced T2 reduction in the superficial cartilage layers. In particular, the T2 of tangential fibers at the cartilage surface appears to undergo a strong reduction due to a load-induced increase of tissue anisotropy.

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