Abstract #2224

Increased Signal Intensity of brain structures on unenhanced T1-weighted images following 35 or more GBCA administrations

Yang Zhang^1,2, Yan Cao¹, George Shih¹, Elizabeth Hecht³, and Martin R Prince^1,4

¹Radiology, Weill Cornell Medical Center, New York, NY, United States, ²Radiology, Qilu Hospital, Shandong University, Jinan, China, People's Republic of, ³Columbia University, New York, NY, United States, ⁴Radiology, Columbia University, New York, NY, United States

In 16 patients with 35 or more linear GBCA administrations increased T1 signal on unenhanced images was observed in dentate nucleus (100%), globus pallidus (100%), cerebral peduncles (100%), substantial nigra (88%), red nucleus (88%), colliculi (81%), posterior thalamus (75%), superior cerebellar peduncle (56%), internal capsule (50%), head of caudate nucleus (31%), body of caudate nucleus (25%) , whole thalamus (25%), pons (13%), anterior commissure (13%), posterior brain stem (6%), pituitary gland (6%), mammillary body (6%) and putamen (6%). The source of T1 signal increase is unknown but may relate to GBCA administration. No clinical significance was identified.

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