1Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, 3Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Medical Engineering and Institute, Department of Engineering Physics, Tsinghua University, Beijing, China, People's Republic of