Abstract #2089

Brain Structural Connectome using PROPELLER Echo-planar Diffusion Tensor Imaging and Probabilistic Tractography

Ya-Ling Lin^1,2, Tsyh-Jyi Hsieh³, and Ming-Chung Chou¹

¹Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ²Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan, ³Department of Radiology, Chi-Mei Medical Center, Tainan, Taiwan

Diffusion tensor imaging (DTI) was demonstrated to successfully trace three-dimensional trajectory of neuronal fiber tracts in vivo and has been widely utilized in many clinical applications. However, there are two major disadvantages when using conventional single-shot DTI, including the problems of intra-voxel fiber crossings and susceptibility distortions. Therefore, the purpose of this study was to utilize PROPELLER echo-planar DTI technique and probabilistic tractography to construct brain connectivity networks. The results showed that susceptibility distortions significantly deteriorated the results of brain connectivity networks and might erroneously enhance the network difference in clinical applications.

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