Abstract #2047

Evaluation of IVIM Perfusion Parameters as Biomarkers for Paediatric Brain Tumours

Emma Meeus^1,2,3, Jan Novak^2,3, Stephanie Withey^2,3,4, Lesley MacPherson³, and Andrew Peet^2,3

¹Physical Sciences of Imaging in Biomedical Sciences (PSIBS) Doctoral Training Centre, University of Birmingham, Birmingham, United Kingdom, ²Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom, ³Department of Oncology, Birmingham Children's Hospital, Birmingham, United Kingdom, ⁴RRPPS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

This study investigated the bi-exponential IVIM fitting methods and their robustness for applications in the brain. Data simulations relevant to normal brain and tumour were computed to assess the accuracy and precision of the IVIM perfusion parameters. The paediatric patient cohort evaluated the correlation between the IVIM and DSC-MRI derived parameters. The simulation results showed that the perfusion fraction (IVIM-f) was robust enough to provide reliable values using the constrained 1-parameter fit. The robustness was further confirmed with the significant correlation observed between the IVIM-f and DSC-CBV. Therefore, IVIM-f could provide an alternative non-invasive perfusion measure for paediatrics.

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