Oscillating Gradient Spin Echo Diffusion Tensor MRI of the Brain in Multiple Sclerosis Patients
Christian Beaulieu1, Corey Baron1, Penny Smyth2, Roxane Billey2, Leah White2, Fabrizio Giuliani1, Derek Emery3, and Robert Stobbe1
1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Neurology, University of Alberta, Edmonton, AB, Canada, 3Radiology, University of Alberta, Edmonton, AB, Canada
In diffusion tensor imaging, oscillating
gradient spin echo (OGSE) gradient waveforms enable much shorter diffusion
times (4 ms) than the typical pulsed gradient spin echo (PGSE, 40 ms) and OGSE
was applied here for the first time in multiple sclerosis patients. A different
dependence on diffusion time would suggest a change in micro-structural scale within
the MS lesions. Compared to normal appearing white matter (NAWM), FLAIR-visible
lesions showed reductions of fractional anisotropy (FA) on both PGSE and OGSE. The
proportional FA decrease between NAWM and lesions was similar for OGSE and PGSE.
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