Tomohiro Takamura1, Shou Murata2, Koji Kamagata3, Kouhei Tsuruta2, Masaaki Hori3, Michimasa Suzuki3, and Shigeki Aoki3
1University of Yamanashi, Yamanashi, Japan, 2Tokyo Metropolitan University, Tokyo, Japan, 3Juntendo University, Tokyo, Japan
Recently, patients with
neuromyelitis optica (NMO) have shown extensive white matter damage, which
could be related not only to Wallerian degeneration resulting from lesions of
spinal cord or optic tracts but also to demyelination by using diffusion-tensor
(DT) MRI imaging. This study aimed to evaluate the expansion of white matter
damage in NMO assessed using neurite orientation dispersion and density imaging
(NODDI), as well as its relationship with disease severity by applying Tact
Based Spatial Statistics (TBSS).
