White matter alterations in young adults born extremely preterm: a microstructural point of view.
Zach Eaton-Rosen1, Andrew Melbourne1, Joanne Beckmann2, Eliza Orasanu1, Nicola Stevens3, David Atkinson4, Neil Marlow2, and Sebastien Ourselin1
1TIG, UCL, London, United Kingdom, 2UCL EGA Institute for Women's Health, London, United Kingdom, 3UCLH, London, United Kingdom, 4CMIC, UCL, London, United Kingdom
We
used NODDI and DTI in order to investigate the differences in white matter
between young adults born at term, and those born at fewer than 26 weeks
completed gestation, using TBSS. The differences in FA were closely mirrored by
the differences in orientation dispersion index (ODI) while the intra-axonal
volume fraction (Vi) did not show significant differences in the
same regions. This suggests that the ODI may be more sensitive to indicators of being
born preterm than Vi in the white matter.
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