Abstract #1974

Estimation of pseudo-diffusion coefficient D* using different settings of low b-values in liver IVIM imaging

Meng-Chieh Liao¹, Cheng-Ping Chien¹, Shih-Han Hung¹, Feng-Mao Chiu², and Hsiao-Wen Chung¹

¹Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ²Philips Healthcare, Taipei, Taiwan

The pseudo-diffusion coefficient (D*) in the liver estimated using intravoxel incoherent motion (IVIM) MRI currently suffers from inconsistent values reported in the literature. This study investigated the effect of low b-value settings on the estimation of D*. Data from healthy subjects with sixteen b-values were analyzed, with b-values of 0, 5, 10, and 15s/mm² selectively removed and D* computed using a bi-exponential model. Results show progressive increases in D* estimations, with difference in values by a factor of two, which strongly suggest that the IVIM signals in the low b-value range do not obey single exponential decaying behavior.

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