Dynamic
Contrast Enhanced MRI is used to assess the integrity of the blood brain
barrier. A major difficulty for the method to be accepted in the clinics is the
variety of pharmacokinetic models used and their strong dependence on the
underlying assumptions and/or acquisition parameters. Thus the far simpler methods
based on signal intensity curve
characteristics are the most commonly used approaches in
clinical practice. In this study we compare two different pharmacokinetic models, the extended Tofts
model and Lawrence & Lee model in patients with primary brain
tumours.
