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Abstract #1930

Hippocampal subfields segmentation derived from Freesurfer 6.0: a multisite 3T reproducibility study in healthy elderly

Moira Marizzoni1, Daniele Orlandi1, Luigi Antelmi2, Flavio Nobili3, Mira Didic4,5, David Bartrés-Faz6, Ute Fiedler7, Peter Schonknecht8, Pierre Payoux9,10, Andrea Soricelli11,12, Alberto Beltramello13, Lucilla Parnetti14, Magda Tsolaki15, Paolo Maria Rossini16,17, Pieter Jelle Visser18, Regis Bordet19, Oliver Blin20, Giovanni Battista Frisoni1,21, Jorge Jovicich22, and on behalf of the PharmaCog Consortium1

1LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine — IRCCS San Giovanni di Dio-FBF, Brescia, Italy, 2Health Department, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy, 3Department of Neuroscience, Ophthalmology, Genetics and Mother–Child Health (DINOGMI), University of Genoa, Genoa, Italy, 4APHM, CHU Timone, Service de Neurologie et Neuropsychologie, Marseille, France, 5Aix-Marseille Université, INSERM U 1106, Marseille, France, 6Department of Psychiatry and Clinical Psychobiology, Universitat de Barcelona and IDIBAPS, Barcelona, Spain, 7LVR-Clinic for Psychiatry and Psychotherapy, Institutes and Clinics of the University Duisburg-Essen, Essen, Germany, 8Department of Neuroradiology, University Hospital Leipzig, Leipzig, Germany, 9INSERM, Imagerie cérébrale et handicaps neurologiques, UMR 825, Toulouse, France, 10Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU Purpan, Place du Dr Baylac, Toulouse, France, 11IRCCS SDN, Naples, Italy, 12University of Naples Parthenope, Naples, Italy, 13Department of Neuroradiology, General Hospital, Verona, Italy, 14Section of Neurology, Centre for Memory Disturbances, University of Perugia, Perugia, Italy, 153rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece, 16Dept. Geriatrics, Neuroscience & Orthopaedics, Catholic University, Policlinic Gemelli, Rome, Italy, 17IRCSS S.Raffaele Pisana, Rome, Italy, 18Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, Italy, 19Department of Pharmacology, EA1046, University of Lille Nord de France, Lille, Italy, 20Pharmacology, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille University-CNRS UMR 7289, Marseille, France, 21Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland, 22Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy

In this study we quantify the across-session reproducibility of hippocampus subfields obtained from the recently proposed ex-vivo atlas tool available in Freesurfer version 6.0. We use structural 3T multisite data from 65 healthy elderly participants scanned twice at least a week apart. We show that several subfields like Cornu Ammonis (CA) 1, hippocampal tail, molecular layer and subiculum offer, despite being smaller, comparable reliability errors to the whole hippocampus volume (2%). This suggests that these subfields may be valid and more specific markers to test disease progression in longitudinal studies, like for example Alzheimer's disease.

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Abstract