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Abstract #1899

Complete partial volume solution for ASL brain perfusion data applied to relapsing-remitting multiple sclerosis patients

Ruth Oliver1,2, Linda Ly1,2, Chenyu Wang1,2, Heidi Beadnall2, Ilaria Boscolo Galazzo3,4, Michael Chappell5,6, Xavier Golay7, Enrico De Vita7, David Thomas7, and Michael Barnett1,2

1Sydney Neuroimaging Analysis Centre, Sydney, Australia, 2University of Sydney, Sydney, Australia, 3Institute of Nuclear Medicine, University College London, London, United Kingdom, 4Department of Neuroradiology, University Hospital Verona, Verona, Italy, 5Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 6FMRIB Centre, University of Oxford, Oxford, United Kingdom, 7Institute of Neurology, University College London, London, United Kingdom

ASL is a low resolution imaging modality that suffers from the partial volume effect, leading to an underestimation of GM perfusion. This effect has two principle causes; blurring from the point spread function in the slice direction, and inadequate resolution due to the need for large voxels to achieve sufficient SNR. Both may act as confounders for measurement of GM CBF abnormalities. Decreased GM perfusion could reflect neuronal loss or metabolic dysfunction; PV correction allows a decoupling of structure and function. We present the first application of a complete PV correction solution for ASL to a cohort of MS patients.

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