Anna Scherman Rydhög1, André Ahlgren1, Freddy Ståhlberg1,2,3, Ronnie Wirestam1, and Linda Knutsson1
1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Department of Diagnostic Radiology, Lund University, Lund, Sweden, 3Lund Bioimaging Center, Lund University, Lund, Sweden
Intravoxel
Incoherent Motion (IVIM) is a method for quantification of perfusion parameters,
such as
the perfusion fraction Fb. Unfortunately, CSF partial volume effects
are often seen in the estimated blood compartment. This work introduces a novel
version of the IVIM model, containing three compartments (tissue, CSF and
blood), where multi-TE and multi-TI data are incorporated to yield a direct
relaxation estimate. Using this relaxation-compensated model, results were
obtained from in vivo measurements in a volunteer. Compared to a
non-relaxation-compensated model, the three-compartment model with relaxation-compensated
data reduced the CSF contamination.
