Abstract #1753

Optimizing the parameter space for functional-MRI in rodents

Georges Hankov^1,2, Basil Künnecke², Markus Rudin^1,3, and Markus von Kienlin²

¹Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland, ²Roche Pharma Research & Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Pharmaceuticals Ltd, Basel, Switzerland, ³Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

In the past years, functional MRI studies in rodents have become increasingly popular. However the parameter space for optimal data acquisition scheme has been poorly explored. In this work, we compare different acquisition methods such as single-shot and segmented Echo Planar Imaging, and PRESTO, to determine which technique offers the best compromise between temporal resolution, geometric distortions, artefacts and signal-to-noise ratio. The results suggest that segmented EPI, using two or three segments, could fulfill the requirements needed for rodent fMRI if ghost artefacts are minimized.

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