Insights in dose dependent effects of Isoflurane by analyzing static and dynamic functional connectivity in mice
Qasim Bukhari1, Aileen Schröter1, and Markus Rudin1,2
1Department of Information Technology and Electrical Engineering, Institute of Biomedical Engineering, ETH and University of Zürich, Zürich, Switzerland, 2Institute of Pharmacology and Taxicology, University of Zürich, Zürich, Switzerland
The neurophysiological
effects of anesthetics on brain functional networks are not completely
understood. In this work we investigated the resting state functional brain networks
under different doses of isoflurane in mice. We used static and dynamic
functional connectivity (dFC) analysis to get insights in dose dependent
effects of isoflurane. The results from dFC analysis show that spatial
segregation across brain functional networks is lost with the increasing dose
of anesthesia thus it may be indicative of a deep anesthetic state. Static
network analysis using dual regression revealed loss of functional connectivity
between the bilateral regions, that is also supported with further results
showing decrease in functional correlations with increased dose of isoflurane.
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