Abstract #1742

Disrupted functional connectivity and structure in the striatum of a mouse model of Huntington’s disease

Qiang Li^1,2, Gang Li³, Qi Peng³, Dan Wu¹, Hanbing Lu⁴, Yihong Yang⁴, Jiangyang Zhang^1,5, and Wenzhen Duan^3,6,7

¹Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Dept. of Radiology, Tangdu Hospital, Xi'an, China, People's Republic of, ³Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴National Institute on Drug Abuse, Baltimore, MD, United States, ⁵Dept. of Radiology, New York University School of Medicine, New York, NY, United States, ⁶Dept. of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Huntington’s disease (HD) is an autosomal dominant inherited neurodegenerative disorder, and several MRI modalities have been used to monitor disease progression. To date, little is known regarding the link between altered functional connectivity and structural atrophy and clinical deficits. In this study, we investigated the functional connectivity and structural changes in a mouse model of HD that recapitulate the key neuropathology and phenotype of HD. Our results revealed significant correlations between functional MRI connectivity and structural atrophy, as well as behavioral performance in the mouse model.

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